Published online ahead of print May 22, 2024, DOI: 10.1200/OP.24.00216

Robert D. Siegel, Kristine B. LeFebvre, Sarah Temin, Amy Evers, Lisa Barbarotta, Ronda M. Bowman, Alexandre Chan, David W. Dougherty, Michael Ganio, Bradley Hunter, Meredith Klein, Tamara P. Miller, Therese Marie Mulvey, Amanda Ouzts, Martha Polovich, Maritza Salazar-Abshire, Elaine Z. Stenstrup, Christine Marie Sydenstricker, Susan Tsai, and MiKaela M. Oslen


To update the ASCO-Oncology Nursing Society (ONS) standards for antineoplastic therapy administration safety in adult and pediatric oncology and highlight current standards for antineoplastic therapy for adult and pediatric populations with various routes of administration and location.


ASCO and ONS convened a multidisciplinary Expert Panel with representation of multiple organizations to conduct literature reviews and add to the standards as needed. The evidence base was combined with the opinion of the ASCO-ONS Expert Panel to develop antineoplastic safety standards and guidance. Public comments were solicited and considered in preparation of the final manuscript.


The standards presented here include clarification and expansion of existing standards to include home administration and other changes in processes of ordering, preparing, and administering antineoplastic therapy; the advent of immune effector cellular therapy; the importance of social determinants of health; fertility preservation; and pregnancy avoidance. In addition, the standards have added a fourth verification.


Standards are provided for which health care organizations and those involved in all aspects of patient care can safely deliver antineoplastic therapy, increase the quality of care, and reduce medical errors.

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